Connectoma and HT Médica bring advanced functional MRI to personalize treatment-resistant depression care
We are joining forces with HT Médica to bring functional neuroimaging to treatment-resistant depression: a model that combines functional MRI, artificial intelligence and neuronavigation to guide TMS with millimetric precision.

At Connectoma we are taking an important step in our mission to make precision neuromodulation accessible: we have formed an alliance with HT Médica, one of Spain’s leading diagnostic imaging groups, to bring advanced functional MRI to the treatment of treatment-resistant depression.
The collaboration launches a personalized-medicine model that combines resting-state functional MRI (fMRI), artificial intelligence and neuronavigation to optimize the planning of transcranial magnetic stimulation (TMS) treatments.
Neuroimaging to treat the circuit, not just the symptom
Depression is not the same in two different brains. Functional neuroimaging makes it possible to identify, in each patient, the specific brain areas that TMS should act upon. Instead of stimulating a standard region estimated approximately, the target is defined from each person’s real functional connectivity.
This approach advances toward a more precise, personalized psychiatry, in which therapeutic decisions can be supported by objective information about how the patient’s brain networks actually work.
What each team brings
- Connectoma brings its experience in clinical care and in personalized neuromodulation treatments.
- HT Médica brings its advanced functional neuroimaging and medical image processing capabilities.
The result is a patient-centered model in which the brain’s functional map guides every treatment with millimetric precision.
You can read the original press release on HT Médica’s website, and learn more about how we apply this technology on our patients page and in the scientific evidence behind the treatment.
Want to talk about your case?
Our team can guide you, with no commitment, toward the personalized neuromodulation treatment that best fits you.
Keep reading

What is transcranial magnetic stimulation (TMS), and how it treats depression
Transcranial magnetic stimulation (TMS) is a non-invasive, drug-free neuromodulation technique that treats depression by modulating specific brain circuits. Here is how it works and what it is used for.
Read more
The Default Mode Network: why the mind never rests (and what it has to do with depression)
When it seems we are doing nothing, the brain still burns enormous energy. The Default Mode Network is responsible — a circuit that becomes hyperconnected in depression and fuels rumination.
Read more
What is neuromodulation, and how it rebalances the brain’s circuits
Neuromodulation retunes the activity of altered brain circuits using controlled stimuli. Here is what it is, the types that exist, and why it is central to precision mental health.
Read more